Just started happening today. I was in Gullet, had triggered the transfer to The Hole (I think that was the name, it was in the southern part of the map) and the game crashed and it hasn't started again since.
I've tried verifying the game files via steam but hasn't resolved the issue.
The only thing that changed for me was I set fullscreen to fullscreen from windowed but had made a few map transitions on this setting before the crash.
Savefile: https://1drv.ms/u/s!Al7-6EHHVJzPi7BHcuQ6ODf9YG7NPw
2018-05-13_180858.zip
DxDiag.txt