I can confirm the the beta patch works with GOG Galaxy. Macbook Pro Mid 2014. Iris Pro 1536. Many thanks to the team at Obsidian for fixing the issue in such a short amount of time!
Same here. Intro in the In-Between runs fine with various graphics settings, then the game crashes once the character reaches the pillar. Macbook Pro Retina Mid 2014, High Sierra 10.13.4. Hoping this gets fixed soon.