After encountering The Scribbler and failing to defeat a Roc I am presented with this screen but the blue arrow does nothing.

 

http://imgur.com/a/tYtg4

I can double confirm to you that the culprit here is the Roc itself and not anything else. On another incident I have only 1 location left and while exploring this only location I encountered a Roc. I failed the check and was unable to resolve Roc's ability. The blue button does nothing and pretty much the game softlocked. Vault trips do nothing, the game is literally frozen.

I have exactly the same problem:all other locations closed, encountering the Roc prior to (second)encounter with the scribbler. Roc undefeated, but blue arrow, although glowing, does nothing.