Getting the snowball rolling

[omgFIREBALLS]

Attacks fortitude, lowers will. Attacks deflection, lowers reflex. Etc etc etc.

 

There seems to be a plethora of ways in which you can mess up an opponent, each effect improving the chances of its successor. But where do you start whittling down your enemy's defenses? I realize of course you could just assault whichever defense is naturally low for the particular creature, but in general, do you have a favorite ability or spell for this?

[mazeltov]

Miasma. Low level spell, long range AoE vs Will. Yields -20 Deflection, -20 Reflex and -40 Will. Even a graze will apply all that stuff for ~15 secs.