The cage cursor setting in options seem to fail after any dialogue. This is a pretty annoying quality of life thing while running two monitors. It'll keep it caged within the game window but always fails after a time. I'm noticing it most after the dialogue window closes. Alt-tabbing out of the game and back into it seems to reset it, but again it doesn't take long for it to fail. 

I'm having the same problem, cage cursor stays ticked but it stops working after a while

I have the same issue, it stops working after a cutscene or after a scripted event/dialogue window opens. I can get it to work again by unticking the Cage Cursor box, saving the options, and then re-ticking the box again but it's at irritating bug.

Yup, same problem.  Still scrolls if I hover over the very edge of main monitor, but doesn't cage.

I have the same problem