The game seems to always default back to the controller every few seconds and hijacks the interface and interrupts my keyboard/mouse input. It's very annoying. Is there a way to disable the controller support for the game?

I have my XBox controlled always plugged into my PC. It is difficult to unplug, just for this game, because it's wired through a case mod. Having a way to disable the controller, even by editing an settings file would be helpful.

I'm fully support. I have the same problem: with a connected Xinput gamepad the mouse in the game does not work. I must to plug it off before starting.