It is a known issue that higher end Nvidia graphics are having many problems with the game, with huge frame drops, memory leaks, and crashes. We are actively working with Nvidia to get the problem resolved, and with the help of our Producer David Benefield we have been able to get Pillars of Eternity II: Deadfire on the Nvidia list of optimized games. This will allow for testing on our end to be better in line with what our community is running and we're working with Nvidia to get a fix for their graphics cards to work as best as possible with our game, but it may take a bit more time.
In the meantime you can attempt to adjust your settings with an article on our support site here. This was made thanks to the awesome help of the community, with a huge thank you to Postenago for making the post.
Thank you all for taking the time to read this post! As always if you do experience crashes feel free to send the information to us, and be sure to add all the files we'd need to get it logged for fixing correctly!