It depends on the type of enemy you are wanting to hurt the most. If you check the bestiary in your journal it will show what type of damage is least effective so you choose the damage type that is most effective against that enemy. I usually have two sets of weapons, one with corrode and another with shock as those appear to be the most frequent damage types. This can be a helpful guide to most effective types of damage against specific enemies: Adragan - slash, burn freeze shock corrode Beetle, adra - crush slash burn freeze corrode Beetle, stone - crush pierce burn freeze shock Beetle, wood - crush freeze shock corrode Blight, earth - pierce burn shock Blight, flame & wind - slash pierce crush shock corrode Blight, rain - slash burn corrode Dragon, adra - crush pierce corrode Dragon, sky - slash pierce freeze Drake - slash crush freeze shock corrode Fampyr - slash crush pierce shock corrode Lurker, forest - slash crush freeze shock corrode Lurker, swamp - pierce burn shock Menpwgra - slash pierce burn freeze shock corrode Ogre - slash crush pierce burn shock Phantom - slash crush pierce shock corrode Pwgra - slash crush pierce shock corrode Revenant - pierce crush burn shock corrode Shade & Shadow - slash crush pierce corrode Skeleton & Skeleton Fighter - crush burn shock corrode Skeleton Ranger - slash crush burn shock Skeleton Rogue - crush pierce burn freeze shock Skeleton Wizard - crush pierce burn shock corrode Spectre - slash crush pierce shock corrode Spider, crystal eater - slash crush freeze burn shock Spider, ivory - pierce burn freeze shock corrode Spider, spear - slash crush freeze shock corrode Spider, widowmaker - crush pierce freeze shock corrode Spore, dank - pierce burn shock Spore, swamp - crush burn shock Sporeling - pierce burn shock Troll - slash pierce freeze shock Vithrak - pierce shock