I've only been able to play the game for a few hours thus far, and one thing I've noticed is that the alchemy skill isn't having all the same effects it did in the Beta. I'm very early in the game, and I haven't been cheating in items, so my observations have been based mostly on Whiteleaf and basic healing potions. Based on quick observations and tooltips, the Alchemy skill longer appears to affect potency of the items-- just duration. (Which, for a basic healing potion, does nothing.) Also the Nalpazca subclass description states that all drug effects are at +10 Power Level, which is the first time I recall seeing Power Level referenced with regard to consumables.
I'm not complaining, mind you. Beta alchemy was rather crazily overpowered, so some nerfing was necessary. I'm just trying to figure out what the rules are here.
I'm planning to test this more thoroughly this evening (I'll update the thread), but in the interim, I figured it was worth getting a thread started to see if anybody else had observations to share.
(Also, it'd be nice if the game had any documentation on Drug Crash effects.)