They are not knew of course, but I didn't find these mentioned on the forum.
Though it is a 2010 game, I suggest fixing these bugs creates player-buyer fidelity towards Obsidian.
1) When loading a saved game at the first check point of a mission, the "script trigger" (my words) does not start, so guards/enemies are not loaded. This happens notably with the mission at the airport in Saudi Arabia. One has to load or start in the safehouse to have the mission trigger its start scripts properly.
2) Silent Running mutes handlers, dialogues, etc. Handler dialogue is important and can give important storyline information. Advanced Silent Running last about 30 seconds. In 30 seconds, everything a handler said was missed (actually happened to me twice).