(I searched Ye Olde Forums and didn't find any mention of this particular topic nor did I see anything in the UI mockup screenshot to assuage my fears, so my apologies if this issue has been discussed already.)
One thing that really bugged me as I started playing Shadowrun Returns is the lack of a game-specific cursor icon. In SRR, the mouse icon is your default arrow (at least in the OS X version) and, I may be alone in this, this tiny detail breaks some of the immersion for me. Therefore, my humble request for Kaz, or whoever is responsible for the final UI design, is to design a set of cursor icons for P:E along the lines of the old IE-style floating hand/gauntlet/other icons. If a gauntlet takes too much space or seems too unwieldy, something equally appropriate and stylized, e.g. something as simple as Starcraft's icons, would be nice.
Another, smaller and unrelated, request would be to add a space between the dash and the character/creature name in the dialogue box. I.e. Osmaer- into Osmaer - . That's just me, though.