I'd hazard to add Torment: Tides Of Numenera to that list, seeing as how you're willing to include Star Wars as sci-fi, when Star Wars is really science fantasy.
What new ground could Obsidian cover with a new science fiction franchise, though? Developing a new setting takes time and dedication. Having dabbled with the subject, I find it to be rather hard, as the setting is supposed to provide good narrative hooks, etc.
I didn't know about that one so thanks for the info. Also i know that it is hard creating a whole universe from nothing but i'm confident that i will pay of, i mean just look at Mass Effect. Even if you dislike Mass Effect you must admit that it's selling good and the new Mass Effect will probably sell good as well even after the disaster of Mass Effect 3. The point is people are hungry for Sci-Fi but the demand is not met.