I played the heck out of Morrowind, modded and vanilla, and have made MODs for it myself. I actually plan on replaying it once http://tamriel-rebuilt.org/ is finished. Daggerfall is definitely on my list and not being taken off Thats why I didn't list it.
I also played the first Vampire: The Masquerade, got halfway through and just completely lost interest. Is Bloodlines better?
BG, PST are must try. Gothic 1 / 2 are initially difficult to get into but well worthwhile.
Proceed to IWD1/2 if you enjoyed the combat and art in BG.
Proceed to Mask of the Betrayer (NWN2 xpack) and KOTOR2 if you enjoyed the writing in PST.
Deus Ex is a weird and unique creature but worth playing for anybody.
Don't bother with NWN1, Jade Empire, these are weaker games in the genre and not classics.
Dragon Age / Mass Effect - you played ME1, so you can make up your own mind I suppose. These are made with a quite different spirit and design philosophy and aren't really in the same ballpark.
BG / PST / Fallout represent in general the turn of the century golden age. If you want to try the older RPGs then Piccolo has noted many of the greats. Ultima VII has very weak combat but represents a good entry point with lots of exploring to do.
Thanks for the insight, I have been interested in BG and PS:T for a while now and the general opinion is that they are must play. Are the Enhanced versions of BG 1 & 2 actually an improvement on the originals or do they just muck it up? I'm willing to pay extra for the better graphics and improved gameplay and tweaks.
Also Neverwinter Nights, Jade Empire, and KOTOR are definitely low on my list, I only listed them for everyone's opinion and purely because Obsidian or Bioware made them. (They seem to be the go to companies for these type of games and are almost sister developers it seems)
I actually started out with JRPGs and haven't played any since FF9 (I also played 7. The series has seemed to go in a direction that I don't like, but I've been interested in the older games) I've always heard great things about Chrono Trigger not so much about Chrono Cross.
I don't care too much about graphics, but if there is an updated version I would prefer to get that. (e.g. Enhanced Version of BG 1 & 2)
Also Fire Emblem Sealed Sword. You can find a emulator, if you're a naughty boy.
I don't care about modding or tweaking. Too much of a time waster and if the game is that broken to need serious MODs or tweaks then I don't want to waste time fixing/playing it. (I'm probably a hypocrite for saying this but Morrowind was the unashamed exception to this rule) If the EE of the BGs is worth it I will definitely get them instead of the vanilla versions.
IWD, dungeon crawler version of BG, noted. If its pure hack-n-slash and no story or dialogue like Dungeon Siege was, then I'm not interested. Then again, DS' combat was horrible. If the combat is addicting I could probably dig it.
Ok FF5 and a GBA game. I heard that there was a lot of good JRPGs on the Game Boys. Will look into, thanks.