I just reinstalled the game and started over. I encountered the same thing. First was the wolf by the springberry. After killing it, it popped back up with minimal hp and couldn't be targeted. I was able to disengage from it. When I came back, it ignored me.
Once inside the ruins, the xaurip did the same thing, but I could not get him to stop following me because one of my characters was stuck in sneak mode. As such, I also could not exit combat mode or save the game.