I have recently played through PoE (twice) and have started Deadfire.
I have managed to keep myself mostly unspoiled on the plot and characters. To the point that the reason I played through PoE back to back was because I didn't know I could change decisions and class upon starting Deadfire.
I went to Neketaka right after finishing up Port Meje and have been here a while.
I have completed multiple quests in each zone. Including the Berathian Priests quest, wizards gloves quest and just finished the old city beneath The Gullet.
I have also tried to push Xoti towards Eder.