A turn-based isometric perspective roleplaying game with a proper system for character customization and a great focus on choices and consequences, dialogue and a reactive world that hasn't already been done a thousand times. (i'm looking at you Nth iteration of vaguely Tolkensian ripoff settings) Everything after that is gravy. Some good inspirations have already been mentioned in this thread, Darklands being prime design idea material in particular. As for world ideas even in just the fantasy genre there's a lot of untouched stuff to take inspiration from. The Sword & Sorcery genre with it's Fritz Leiber's Fafhrd & The Grey Mouser, Clark Asthon Smith's Zothique, Hyperborea and Averoigne, Lord Dunsany's Pegana, REH Howard's Hyperborea, Jack Vance's Lyonesse and Dying Earth, the list goes on. SF have several genres/tropes no one seems to have touched on in games very much, like the possibility of First Contact. Supernatural Modern World but with your own take might be interesting seeing as Vampire: Bloodlines still has a pretty huge following and making all those myths and silly ideas be true can be fun in it's own right. Just a Modern world or Historical setting could be pretty great as well, even if it might bring in the ol' "let's debate realism!" crowd. Well done 2D with hand-drawn backgrounds and all seem to age better and certainly calls out the nostalgia of the genre a bit more. If not that then perhaps 2D backgrounds with 3D models might be an idea? As much as people are calling for a sequel I can't help but feel it's a bad idea. The licensing concerns alone would probably eat up the kickstarter budget and more, and doesn't it pretty much kick the entire Kickstarter appeal of not being at a publisher's yoke and call to the curb?