Well, I realize that's a large number. There are over 600 mods over on Nexus, many of them really interesting. And from my experience with using mods (which goes back a good amount... I remember a 100+ modlist for Skyrim), as far as the different systems working in the engine, I think if you try to focus on only adding smaller mods that adjust minor and dissimilar aspects of a game's engine (while having a somewhat logical understanding how the engine works), you are usually OK. At least that's what I'm trying to do.
There are many mods, but not many "Overhaul" types that change multiple aspects at once. Think Witcher 3 combat overhaul mods. I'm not using anything like that.
But regardless, and yes I will likely end up having to troubleshoot issues with that many.. I expect that... but I'm just having trouble finding any resource online that breaks down what (if any) types of mods need to be given priorities over others in the in game load list, aside from the handful of mods that do specify it in their descriptions.