Literally "Rocks fall, everyone dies" the bug. Neat.
I recently had my game start the unresponsive mouse thing after 140 hours. Sold the billion items I had in inventory, deleted 500 extra saves and failed restarts, verifying files now. We'll see if it stops. SUPER annoying trying to sell a ton of junk when every mouse click has to be clicked 3-4 times before it'll register, and sometimes when trying to sell in bulk it will start sliding down from the top amount without stopping when you just want to sell all but one.
ETA: Turning off steam overlay worked. Guess it was the recent steam update, although the problem started several hours after the update. Yay computers.