Same problem, trying to follow the Painted Masks plotline with Aloth.
Followed the Vailian questline and killed the pirates at Crookspur, freed all the slaves.
Went to Ori o Koiki and looked at the mural and offering bowl and other things with evidence of the Leaden Key.
Spoke to Rusana. No matter what choice I select with her, she stops talking to me. I cannot read her soul and continue Aloth's quest.
Help!