Jokerswild

I read a number of older posts with regard to this same issue, but it seemed that the only real fix for it would be to just start a new game? I am hoping there is another way because I really don't want to start a new game if I don't have to... The quicksave/restart option does absolutely nothing for me. I noticed that once I got to the Gilded Vale, this issue started happening. I will often notice important items that I want to pick up, but can't. Unlike some others who would notice their icon change to the hand icon and hear the sounds of their character opening a drawer or rummaging through something, I get nothing. My icon never shows the hand icon and nothing happens when I try to click on an area highlighted in blue or any areas where the magnifying icon pops up. It is discouraging because this is a really fun game and I want to continue playing without all these major issues. Can anyone help me fix this?