I have the same problem. In town, going in each house can take upwards to 15 seconds, then leaving the house will take even longer (>20 seconds). I tried removing old save files and using iemod to turn off autosaves but the slow loading is still there.
I'm using a new gaming pc with 16 GB ram and Samsung EVO SSDs and the load times are unbearable. Tyranny inspired me to load up PoE for the first time in about a year to see if the loading screens were still a problem...I stopped playing after 5 minutes, most of which was spent on loading screens, and after seeing that Tyranny shares the same loading screens, I've decided against purchasing it. I wonder how many other potential customers are lost because of this issue.