Alpha Protocol 2 is not happening. Nope.
However, a spiritual successor, one that takes the core concepts and mechanics and builds on them? I would love that. That kind of intricate, multi-path storytelling is something I really enjoy - and something more games should try to do.
I have no idea if there's any probability of that happening (zilch to none, perhaps), but I can dream...
That said, if someone did make a sequel to Alpha Protocol - direct or spiritual - I would really hope they overhaul the combat system. Cuz that ... that was not great.