While re-running Approach to Thistletop on normal difficulty with Merisiel, Kyra, and Seoni, two of my characters hands became scrambled with cards being layered over each other, making some inaccessible. I closed the program, rebooted it, and jumped back into the scenario to find that the cards that all of my characters had in their hands were gone, just deleted completely, leaving them with only what they had in discard and in their deck.
A little disappointed over this. I had worked for several hours to build those decks in order to get through Thistletop Delve, and I lost several that were pretty important.