I have a similar issue with the load and continue buttons being greyed out. I'll be playing fine but if i exit and restart the game same issue. I found the work around in another thread and have used it. Deleting the obsidian folder in the locallow and local directories under users. I never finished the game before the DLC came out and started a new character and game to play all the way through. I was hoping to find if their is a fix in the works for this or I may be putting the gam eon the shelf till its fixed.
Thanks