I also got this bug where the whole sanitarium became enemies with me, but I was still able to continue the main quest, not realizing that this was actually a bug. Now, 10 hours of play later, I have a quest to turn in some items to Nans, but I can't because she attacks me on-sight.
This is the 2nd game-breaking bug I've found, and I have to say it's hugely discouraging. It makes me afraid of playing the game at all.