PC unable to mouse click in game

[BigPapaTunde]

So the game is not allowing me to click on anything unless I alt-tab, then I am able to click once and then must alt-tab again if I want to click another time. This basically means I cannot play, the only solution I've found is changing resolution so it is the same as the monitor, which it already is... I tried switching resolution and from fullscreen to windowed etc, nothing has worked. I just want to play.... Anyone got a solution? I saw a solution on another post to press Alt-Enter, this fix has not worked for me.