I'm currently playing on PC (Windows 10) and I am unable to save my game. I am not on Supernova difficulty (I'm playing on Normal) and the Save Game option is just grayed out. There's also no response when trying to use the Quicksave button.
I got up to the part where you get your first companion and was not able to save all the way up to this point. The game also did not auto save in any fashion, so when I had to quit the game and come back later, all of my progress was gone and the Load G