Running 3.02 on Win 10 just after a Win 10 update, "Cumulative Update for Windows 10 Version 1607 for x64-based Systems (KB3213986)". Invoked Pillars of Eternity (installed via GOG) and found the Continue and Load buttons grayed out. Followed this issue through several forums, and have deleted the files in the AppData areas, ensured that the Pillars of Eternity exe was invoked as Admin, and reinstalled POP. Since the New button was not greyed out I did succeed in creating a new game but the reloads from those saves were also hidden behind the greyed out Continue and Load buttons so even restarting a game is not an option. I have basically tried all of the suggestions in the various forums, but if others are having the same problem that I'm reporting, it is not currently clear to me.
I've done a bit more investigation. I found the GOG location for the output_log.txt file in C:\Gog Games\Pillars of Eternity\PillarsOfEternity_Data\output_log.txt. It reported errors in the savedfiles as ZIP FILE WAS CORRUPT. It reports this if the only savefile that was available was the last one saved, the first one saved, or a new one from a newly started game. So files that had worked before to Continue or Load games from were now reported as corrupt even though the timestamp on those files had not changed. All of the tested savegames file were not marked as readonly. In each test I deleted the AppData areas suggested and ensured the exe was invoked as admin.
My conclusion is that the savegames files are not at fault. Either the program itself is manifesting an error or the OS environment change is manifested a bug in the program. One other change was that I deleted Chrome from my system because after switching to Developer mode and load Win 10's Bash environment, it started invoking on startup which I didn't care for. A red herring, likely, but a change in environment none the less.
I would like to continue with my level 12 Cipher. Would be okay with starting over if I could be assured I could complete the game. I've enclosed the output_log.txt file from the fresh new game start and my DxDiag.txt file. I also included the new savedgame files as zip files.
output_log.txt
DxDiag.txt
b202e6f7-364c-45bd-b3c7-feac87678e76 autosave_0.savegame.zip
b202e6f7364c45bdb3c7feac87678e76 7656255 Encampment.savegame.zip