If you charm an enemy and there are no uncharmed enemies remaining, combat will end.
Then the charm effect will wear off, and you can't re-enter combat.
The hostile enemy will just stand there, not attacking, but regenerating health.
As I progress further into the game, the amount of time it takes to quicksave is increasing.
At the beginning of the game, quicksaves were virtually instantaneous.
I am now in Act 3, and it takes about 8-10 seconds each time I quicksave.
Link to my latest savegame: https://dl.dropboxusercontent.com/u/57880242/fda4e71c-3ad4-44a3-8ede-567abd0263de%20quicksave.savegame