Please make a game set in the Planescape: Torment setting! Just hire an awesome, thoughtful writer. Lore is already there, you just need a decent (preferably awesome), rather subversive storyline and fleshed out characters (not men on steroids and women in thongs with +100 armor - those are seen much too often lately). And don't make a sequel, instead let us bump into old characters (now NPC-s) and visit all the old places.
I think we had enough of pure fantasy and pure SF.
PT really has the best lore ever, and it's so flexible: you can go berserk with creative ideas.
If I could get only one wish in the gaming industry, I would spend it on this.