Oddly I have had the same problem and error message while playing Fallout New Vegas. O_o Everytime this message would pop up I would have to either press cancel or continue several times for it to go away, and then I closed New Vegas. I finally did just let NV go ahead and wait to respond however and that actually solved the issue. Maybe you could try the same?
"There is no disk in the drive. Please insert a disk into drive \Device\Harddisk\DR2"
in PC Support
Posted · Edited by nayrunyan
Oddly I have had the same problem and error message while playing Fallout New Vegas. O_o Everytime this message would pop up I would have to either press cancel or continue several times for it to go away, and then I closed New Vegas. I finally did just let NV go ahead and wait to respond however and that actually solved the issue. Maybe you could try the same?