I just hope that whoever is writing up NWN2 does a bette job than the original team. On that note, I too am curious if Wizards has any final say on the matter, since it's their product (DnD) and ultimately will reflect on them.
I remember seeing a "Baldur's Gate" novel after the game became a major hit. And I do think they included the "Bhaal" saga on the official FR timeline. That's no small accomplishment for a game.
Now, Neverwinter Nights' poorly developed main plot probably won't make it to the "novels" or the offical FR chronicles.
I would love to see a return to "Obsidian origins" with NWN2. I remember how the Golden Box series were all based on the great books TSR published back in the day. I would love to see an adaptation of a book, or a recounting of a famous official "novel" through the eyes of a different character. I would like to see Obsidian game writers use the material in Forgotten Realms so that we, as community developers, don't have to cringe at how game developers try to reinvent the wheel, introduce new characters, or twist completely organizations and characters that are already known in the setting.
I wish the best to whoever is dealing with writing the story of NWN2. Hopefully you won't pick where they left off in terms of "story". Both the expansions were weak too. I found myself playing the "side quests" and refraining from following the major plot, or otherwise distracted with the multitude of mini quests.
Follow ONE story. Follow the "official" occurrences in the FR setting. If there's need for side-quests (and there are) make them relevant, yet generic so all characters can experience them. And make them unique with scrips, so that the game experience changes if you play with different races, classes and alignments. The game will last longer if you can enjoy playing it again.
You are carrying the brand "Forgotten Realms", it should feel like you are in the setting. NWN made me feel like I was in a game that was based on FR, but did little to make me "feel" in the novels and campaign settings. I wish that to change in future games. I want to witness in-game what I read in the campaign setting. I want to meet the legendary characters, fight the epic battles, slay the greatest foes. Or at least try.
That's just an opinion of a community developer who had his time playing the original game and decided to create a PW where you could really feel like you were in the Realms.
