I've noticed anytime there's an O.R.C. invasion at my base and I run away to end the event, my game crashes. It seems to happen as the creatures begin to de-spawn and the Stranger does her dialogue.
Additionally, during fights with larger creatures (Wolf Spider, Northern Scorpion) I've had some pretty massive lag. For instance, I'll see the Wolf Spider wind up for an attack and I will raise my shield. The game will jitter, will skip the frames of the spider attacking, and then will register a hit against me.