I just got to the mission on Monarch where you have to get to Carlotta. I got past Niles and then I went into the building on the left where you can hack the terminal to blow up the generator. I did that not sure what it did and it killed me and all my companions. It then went to the death screen where continue and load game were both blacked out. I hit main menu and the it brought me to the loading screen and it just stayed in the loading screen forever. Music playing and guy in bottom moving with tips on bottom changing. I then decided to exit game to main Xbox menu and close out then go back in. Then it brings me to ship where I hit A and the music plays but the ship freezes. Currently I am uninstalling and reinstalling to see if that corrects the issue and will update after.
Update: I uninstalled and reinstalled as well as Hard reset my Xbox (was finding out other games were freezing on load screens as well) and now was able to get past ship to continue game.