Sending this along for whatever it might be worth. Platform: PC (Mouse and Keyboard), i7-7700, 32GB RAM, RTX 2070
1. "Fistful of Digits" - digits apparently do not spawn if the quest is not active. Dealt with two of the three targets prior to taking the quest and did not receive the quest objects with their loot (might be related to #2). After taking on the quest, the third worked as intended and I got the appropriate quest reward for turning it in, but was unable to complete the quest due to the absence of the other two. Their bodies despawned, apparently as intended, so the objects could not be retrieved after accepting.
#2. Some enemies do not allow looting. This is particularly true of marauders on the first world, though it happened with others such as primals. The body highlights for looting, but the loot window immediately closes when activated and nothing is transferred to inventory. See #1 for how this might be affecting a named quest.
#3. Quest markers do not work within the journal. The only quests which seem to generate markers are the main storyline quests and even those are a bit iffy once you leave the first world. Secondary quests are listed in the journal and can be selected, but they either generate no marker or the marker reverts to the storyline as soon as the journal is closed.
#4. (Cosmetic) Lighting discrepancies between the character creation screen and the character screen in-game result in much darker skin tones in-game than anticipated in the creation screen. I was aiming for a kind of dusky Mediterranean look and ended up with more of a south or southwest Asian tone. This is strictly a cosmetic thing and has no impact on gameplay.
I have only spent a short time on the Groundbreaker, so cannot comment on anything later in the game, but those were the really annoying ones from the start of the game.