Steps to re-create ..
1) Have a Macbook Pro
2) Buy PoE2 and install it
3) Attach a display (set to scaled 1080p).
4) Move PoE2 window to display
5) Select 1080p (which goes to full screen)
6) Enter an interaction. Screen goes blank.
Now, if you swap off and swap back on the dialog options become briefly visible (sometimes they stay visible). The only fix for this is to, of course, force quit the game and wait for it all to reload.
This worked fine with PoE which I finished not that long ago so it is probably not a Unity issue.
EDIT : Happens in windowed mode too on the display. Use the built in display and its fine.
Model Name: MacBook Pro
Model Identifier: MacBookPro13,2
Processor Name: Intel Core i5
Processor Speed: 2.9 GHz
Number of Processors: 1
Total Number of Cores: 2
L2 Cache (per Core): 256 KB
L3 Cache: 4 MB
Memory: 16 GB
System Version: macOS 10.14.3 (18D109)