Another hint: Disabling the Steam overlay also didn't help.
Please: I really look forward to this game, I backed PoE2,I payed full price for PoE1 and I also bought Tyrrany, This is a serious issue, the game is almost unplayable. I want technical support, I don't want to be ignored. I am a senior cross-platform software engineer myself, and I know the bugs do always happen, but I also know that with sufficient effort all bugs can be fixed.