There's a chest (House Doemenel) that says it requires 6 Mechanics and 7 Lockpicks OR 7 Mechanics to open.
I have a 6 Mechanics Character, and 8 Lockpicks in her inventory (it is my main character). The top part of the mouseover is even white! The THING WON'T OPEN. I've tried reloading, moving the lockpicks into the stash / back. What the hell?!