The thing a lot of you are missing is that it's a joke about a situation that often ends, not in suicide, but in a woman being murdered. And often times, at least in America, the killer getting away with it. There's serious bigotry involved with the situation, including the very idea that transwomen are men trying to trick you instead of, y'know, women.
Now, the backer probably didn't intend any of that. But that doesn't change the connotations of the joke. It added nothing to the game, makes light of deadly bigotry, and is insulting to a marginalized group. Why defend that?