Workaround for the game loading and saving from different paths as described above:
(assuming your network Path is \\VOS.VOSDOM.LAN\Documents\weber\Documents\My Games\Pillars of Eternity II )
* create a folder C:\VOS.VOSDOM.LAN\Documents\weber\Documents\
* open powershell and execute
New-Item -ItemType Symboliclink -Path 'C:\VOS.VOSDOM.LAN\Documents\weber\Documents\My Games' -Value '\\VOS.VOSDOM.LAN\Documents\weber\Documents\My Games'
This will be accepted by PoE and you can load and save both from the network folder.