I can skip the Obsidian/Paradox/Kickstarter splash screens with a mouse click, and I can see the hand cursor on the main menu, but I can't interact with the menu. I can't start a new game, see options, exit, or do anything. None of the keys on my keyboard have any effect either, though I don't know if they're supposed to. All I can do alt-tab out and close the game from the taskbar.
This is with the Steam version, 1.0.2.0508, running on 64-bit Windows 7 SP 1, if that helps.