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Sacrificing a scripted NPC to the Blood Pool in the Temple of Skaen outside of Dyrford will give the following bonuses:

 

  • Aloth: +1 Int, +5 Reflex.
  • Eder: +1 Mgt, +5 Deflection.
  • Durance: +1 Con, +5% Max Stamina.
  • Grieving Mother: +1 Resolve, +5 Resist Affliction.
  • Hiravias: +1 Dex, +1 Damage Threshold.
  • Sagani: +1 Perception, +2 Bonus Accuracy on same enemy.
  • Kana: +1 Int, +5 Resist Affliction.
  • Pallegina: +1 Resolve, +1 Damage Threshold.

You have to have Cruel 1 or 2 to get the option.

 

There is a good list here of talents you can get as part of the story.

Edited by RtrnofdMax
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Note that grabbing an NPC, even just to sacrifice to the Blood Pool, will void your ability to get the solo achievement, so that one might be off limits.

 

This link will show you the rest. Second Skin, The Merciless Hand, and Mob Justice are mutually exclusive means to get to the end of Act II. Dungeon Delver and Wild Running are mutually exclusive rewards depending on how you resolve At the Mercy of the Tribes. Gift from the Machine requires you to send Icantha's prisoners up the tower rather than rescuing them, this will give you Deceptive and Cruel points. Scale-breaker requires you to make a deal with the Adra Dragon and then betray her when talking to the dragon-hunter. The deific boons are all mutually exclusive, and it might not be possible to get Wael's Boon (I didn't have the option on my most recent run).

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You can get one Effigy's Resentment talent during Blood Legacy.

 

There's the Defiance Bay faction-specific talent... again, only one.

 

+Perception from Song of Heavens (getting songbirds for Delem).

 

One of two talents, depending on how you resolve At the Mercy of the Tribes.

 

And a minor DR boost from saving Alwah from Noonfrost.

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Sacrificing a scripted NPC to the Blood Pool in the Temple of Skaen outside of Dyrford will give the following bonuses:

 

  • Aloth: +1 Int, +5 Reflex.
  • Eder: +1 Mgt, +5 Deflection.
  • Durance: +1 Con, +5% Max Stamina.
  • Grieving Mother: +1 Resolve, +5 Resist Affliction.
  • Hiravias: +1 Dex, +1 Damage Threshold.
  • Sagani: +1 Perception, +2 Bonus Accuracy on same enemy.
  • Kana: +1 Int, +5 Resist Affliction.
  • Pallegina: +1 Resolve, +1 Damage Threshold.

You have to have Cruel 1 or 2 to get the option.

 

There is a good list here of talents you can get as part of the story.

 

These bonuses are outdated, the second bonus you get is much weaker now - Eder gives just +2def, the damage reduction from Hiravias/Pellagina is vs 2 types of damage only, the resists from Kana/mother work only vs 2 minor effects, etc...

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