Umm If I recall correctly the start of the game is going to have the player character witness an "earth shattering event", I think that a single starting location is almost required for that.
If by "location" you mean like... city or area, then yeah. But, you could still start in different spots. Although it's possible, I wouldn't assume that the very start of the game is LITERALLY your character witnessing a supernatural event, kind of like how the start of the Lord of the Rings isn't Frodo setting out for Mt. Doom.
You could start in different parts of the outskirts of a city, or even different parts of a city, itself, and have different prologue "companions," and different interactions with the very same NPCs within that city, even, and STILL end up witnessing the very same event that every character in every playthrough witnesses to kickstart (pun alarm) the main portion of the narrative storyline.
The witnessing of the supernatural event is like a chokepoint between areas. Plenty of factors before AND after it can be totally different.
In fact, what might even be pretty interesting is if all the backgrounds are in some way affiliated with the starting city/area, and they're all "there" no matter what. In other words, if you COULD be a farmer entering the town for the day to sell his crops, or you COULD be a mercenary brought into town to help the militia with something, then, as the mercenary, you actually can bump into the farmer (who, now, simply isn't you, and therefore doesn't end up witnessing the supernatural event), and vice versa.
If that farmer is Cedric's nephew, from the Salnor farm, then, even if YOU don't choose that background, an NPC who is Cedric's nephew from the Salnor farm could be wandering around town, between the gate and the market.
Personally I'm assuming that the "earth shattering event" will be after a short prologue. And I assume that when people are talking about "different locations" then they are talking DA:Origins style.
What you are suggesting could work, with just the first 30 minutes being a bit different but with the rest of the game being largely unaffected. It sounds kind of neat actually and wouldn't even take that much time and effort.
Edited by moridin84, 17 July 2013 - 03:03 PM.