Well, given that MS also owns inExile, and that they will soon release Wasteland 3 as a turn-based isometric RPG (like the last one), I'm feeling confident that Obsidian will be able to release a Pillars of Eternity 3 as we know and love, but better if they wish to.
I am also sure that POE 3 will be the next big project from Obsidian
No it won't. Sawyer has made it very clear he wants a nice long break from PoE
They can make PoE3 without Sawyer. Sawyer wasn't even the director the PoE2 DLCs.
They can, but they won't.
But there's no harm in holding on to your dream.