Eh, I like both games so I don't see need for Obsidian to do radical changes, but if they do, I would always be happy with switch to turn based combat :D
That aside, story wise I'd just like to see game setting in either a) Yezuha b) Living Lands c) White that Wends. Mostly because those three are areas I'm interested in learning more about. Not that other countries aren't cool or interesting, but they seem most "familiar" to me if that makes sense?
Out of the three, I'd prefer White That Wends, but I expect it the least.... It's supposed to be a snowy, barren land with wandering tribes. The tribes moving around would be an annoying mechanic, and all the scenery would be pretty much the same. It wouldn't actually sort out for a good place to base a game on.
As for Juanval's comment... A 'new' character could be good... But TBH, WHY are we all so stuck on Eora? Obsidian made Eora, we can have faith they can make a NEW land. With Eora as it stands, at the end of Deadfire, it would be basically impossible to avoid the consequences of the first two games, and avoid the gods, without it feeling horribly contrived. Why not make a NEW land, with a similar system to POE, advertise it as 'being based on the Pillars of Eternity game mechanics' or some such, and go from there?
The more you extend an IP, the more the built-up lore and expectations limit what you can or cannot do. At this point, it's pretty heftily restrictive to try to justify a lore-friendly POE 3 with the Watcher, or one without the Watcher that doesn't interact with the gods. So, why do it? Why labor under countless restrictions when you could start anew?
Make a new IP, one that doesn't involve direct influence by gods, only Priests. Make the gods background dressing, and you can even keep Godlikes around, giving them something similar to Faith and Conviction, but unique to each God. That way, gods are THERE, they have influence, but they speak to noone and never directly interfere. We've kept some of the good things about Pillars, but freed up the narrative for new plots, plots that won't restrict or affect the following games as much.
Tyranny was an interesting universe, even if the game itself still feels unfinished because of how much was left un-done in the game. This new Outer Worlds or whatever should at least be an interesting lore-wise kind of thing, regardless of the game's overall quality. Obisidian has proven they can and will make interesting new worlds if they want to... Why not do THAT and have a POE3 that isn't named POE, and isn't in Eora, but still has that high fantasy style and the game mechanics we love?